When considering the process of policy-making on menstrual hygiene management (MHM) issues, the roles of politicians, journalists, lobbyists, and interest groups tend to be the focus. Less often considered is the role of the wives of politicians, both national and local, as change-makers for female-focused policy, including issues pertaining to menstrual health. Here, we review the instrumental role of the wives of leaders, or “first ladies,” of several countries in keeping menstrual health on the political and media forefront.